In-Vivo Gene Therapy with Foamy Virus Vectors
نویسندگان
چکیده
منابع مشابه
Foamy Virus Vectors for HIV Gene Therapy
Highly active antiretroviral therapy (HAART) has vastly improved outcomes for patients infected with HIV, yet it is a lifelong regimen that is expensive and has significant side effects. Retroviral gene therapy is a promising alternative treatment for HIV/AIDS; however, inefficient gene delivery to hematopoietic stem cells (HSCs) has so far limited the efficacy of this approach. Foamy virus (FV...
متن کاملNonintegrating foamy virus vectors.
Foamy viruses (FVs), or spumaviruses, are integrating retroviruses that have been developed as vectors. Here we generated nonintegrating foamy virus (NIFV) vectors by introducing point mutations into the highly conserved DD35E catalytic core motif of the foamy virus integrase sequence. NIFV vectors produced high-titer stocks, transduced dividing cells, and did not integrate. Cells infected with...
متن کاملEfficient liver gene transfer with foamy virus vectors
BACKGROUND Liver gene transfer offers hope for the correction of genetic and acquired disorders. Efficient gene transfer in large animals can be obtained with hydrodynamic gene transfer (HGT), a method that can achieve sufficient levels of gene delivery. MATERIAL AND METHODS To test the relative efficiency between plasmid versus foamy virus (FV) vector-based liver gene transfer efficiency, we...
متن کاملDevelopment of Foamy Virus Vectors for Gene Therapy for Neurological Disorders and Other Diseases
The complexities of neurological diseases make it difficult to develop effective methods to treat them. In addition, it is difficult for the drugs used in neurological diseases to reach target cells at a sufficient concentration due to the blood-brain barrier, which may lead to side-effects in other organs, even though newly developed drugs are targeted directly to the origin of the diseases. N...
متن کاملGene therapy with herpes simplex virus vectors.
Gene delivery to the nervous system represents perhaps the ultimate challenge of gene therapy in view of the complexity of this system, the wide variety of intractable neurological diseases and the need to deliver the gene to non-dividing cells. Although a variety of systems for such gene delivery are under development, herpes simplex virus has unique advantages in terms of its large genome siz...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Viruses
سال: 2019
ISSN: 1999-4915
DOI: 10.3390/v11121091